Instinct MI355X vs Instinct MI300X
AMD Instinct MI355X (CDNA 4, 288 GB) against AMD Instinct MI300X (CDNA 3, 192 GB): memory, compute, power and rental price, compared for LLM inference and training.
Pick two GPUs to compare
Side-by-Side Specifications
| Spec | Instinct MI355X | Instinct MI300X |
|---|---|---|
| Architecture | CDNA 4 | CDNA 3 |
| Memory | 288 GB HBM3e | 192 GB HBM3 |
| Memory bandwidth | 8,000 GB/s | 5,300 GB/s |
| FP16 tensor compute | 5,000 TFLOPS | 2,615 TFLOPS |
| INT8 tensor compute | 10,100 TOPS | 5,230 TOPS |
| Interconnect | Infinity Fabric 4 · 1075 GB/s | Infinity Fabric 3 · 896 GB/s |
| TDP | 1400 W | 750 W |
| Est. on-demand price | ~$13.00/h | ~$6.00/h |
| FP16 TFLOPS per $/h | 385 | 436 |
Highlighted values indicate the stronger spec. Hourly rates are indicative on-demand estimates.
Verdict
Raw performance: The Instinct MI355X leads on FP16 tensor compute (1.9x advantage), which translates directly into higher token throughput for inference and shorter training steps.
Memory: With 288 GB per card, the Instinct MI355X fits larger models on fewer GPUs — fewer cards means less inter-GPU communication and simpler deployments.
Value: At current on-demand rates, the Instinct MI300X delivers more compute per dollar (436 vs 385 FP16 TFLOPS per $/h). If your model fits in its VRAM budget, it is usually the more economical choice.
GPUs Needed for Popular LLMs
Cards required to serve each model at 8-bit quantization (with 20% overhead for activations and KV cache).
| Model | VRAM (8-bit) | Instinct MI355X | Instinct MI300X |
|---|---|---|---|
| GPT-5.6 Sol | 2682 GB | 10x | 14x |
| DeepSeek V4 Pro (671B) | 750 GB | 3x | 4x |
| Muse Spark 1.1 | 335 GB | 2x | 2x |
| Claude 5 Sonnet (175B) | 196 GB | 1x | 2x |
| Nova Premier (80B) | 89 GB | 1x | 1x |
| Nova Core (34B) | 38 GB | 1x | 1x |
| Nova Lite (12B) | 13 GB | 1x | 1x |
| Phi 3.5 (3.8B) | 4 GB | 1x | 1x |
Frequently Asked Questions
Which is better for LLM inference: Instinct MI355X or Instinct MI300X?
The Instinct MI355X delivers more raw FP16 compute (5,000 TFLOPS) and the Instinct MI355X offers the most memory per card (288 GB). For cost-efficiency, the Instinct MI300X currently gives more FP16 TFLOPS per dollar of on-demand rental (436 vs 385 TFLOPS per $/h).
How much more memory does the Instinct MI355X have?
The Instinct MI355X has 288 GB of HBM3e versus 192 GB of HBM3 for the Instinct MI300X — a ratio of 1.50x in favor of the Instinct MI355X. More VRAM per card means fewer GPUs to fit a given model.
Is the Instinct MI355X or the Instinct MI300X cheaper to rent?
Estimated on-demand rates are ~$13.00/h for the Instinct MI355X and ~$6.00/h for the Instinct MI300X. Raw hourly price is only part of the story: normalize by throughput (TFLOPS per $/h) and by how many cards you need for your model's VRAM.
How do the Instinct MI355X and Instinct MI300X compare on power?
The Instinct MI355X has a TDP of 1400W versus 750W for the Instinct MI300X. FP16 compute per watt: 3.6 vs 3.5 TFLOPS/W.
Deploy on a GPU cloud
Rent the Instinct MI355X or Instinct MI300X by the hour instead of buying hardware.
